BioMed iLab-Zhang Group at Sun Yat-sen University


Xudong  Zhang, Professor
Principal Investigator,
Department of Pharmacology,
Molecular Cancer Research Center,
School of medicine,
Sun Yat-Sen University.

Prof. Zhang received his Ph.D. degree from the School of Life Sciences in Tsinghua University. he was a postdoc associate in the laboratory of Prof. Chengyu Liang at the Keck School of Medicine at the University of Southern California in 2015-2016. Then he joined the laboratory of Zhen Gu at North Carolina at Chapel Hill, and UCLA in 2016-2018. Prof. Zhang joined in School of Medicine at Sun Yat-Sen University in the end of 2018 as a "Hundred Talents Program" fellow. Prof. Zhang was selected in “Shenzhen Excellent Science and Technology Innovation Talent Training Project (Excellent Youth Project) ” and “Overseas High-Caliber Personnel” in 2021.

RESEARCH INTERESTS
Cancer immunotherapy
Extracellular Vesicles EVs
Type 1 diabetes
Intelligent drug delivery
News
2024

Jan. 05:  Our paper named " Harnessing Enucleated Cancer Cells as Trojan Horse Cell Vaccines" has been published on  Cell Reports Physical Science !

2023

Oct.10: Yuan Li and Yumeng Ma won National Scholarship, and Zhangyan Jing Won Biomedical Scholarship, congratulations to Guys!

Oct 9：Welcome Xinyu Ye to join our lab as  Postdoc. !

Sep 29:  Our paper entitied "In situ immunomodulation of tumors with biosynthetic bacteria promote anti-tumor immunity" has been published in Bioactive Materials!

Jan 21: Our paper entitied "Engineered Cell Membrane Vesicles Expressing CD40 Alleviate System Lupus Nephritis by Intervening B Cell Activation" has been published in Small Methods !

2022
Dec 27: Our paper entitied "Engineered IL-15/IL-15Rα-expressing cellular vesicles promote T cell anti-tumor immunity" has been published in Extracellular Vesicle !

Dec 05: Our paper entitied "Biosynthetic neoantigen displayed on bacteria derived vesicles elicit systemic antitumour immunity" has been published in Journal of Extracellular Vesicles !

Nov 02: Our paper entitied“Leverage biomaterials to modulate immunity for type 1 diabetes" has been published in Frontiers in Immunology !

Oct 16: Zhirang Zhang won the National Scholarship, congratulations!

Oct 10: Our paper entitied“Engineered T cell extracellular vesicles displaying PD-1 boost anti-tumor immunity" has been published in Nano today !

Mar 21: Our paper entitied “Cellular vesicles expressing PD-1-blocking scFv reinvigorate T cell immunity against cancer” has been published in Nano Research !

2021
Oct 26: Tianyuan Xue won the National Scholarship, congratulations! Apr 7: Our research article entitled “Genetic engineering cellular vesicles expressing CD64 as checkpoint antibody carrier for cancer immunotherapy” has been published online in Theranostics !

2020 May 25: Our paper entitied “Engineered PD-L1-Expressing Platelets Reverse New-Onset Type 1 Diabetes” has been published in Advanced Materials ! 2019 Feb 28: Our paper entitied “Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation” has been published in Journal of Controlled Release ! Mar 26: Our paper entitied “Surgical Tumor-Derived Personalized Photothermal Vaccine Formulation for Cancer Immunotherapy” has been published in ACS Nano !

2018 Dec 1: BioMed iLab officially opened.

Selective Pubulications

1. Z. Jing#, W. Fang#, X. Li, #, Y. Tian, Y. Li, C. Zhang, Z. Yang, C. Li, Fanqiang Meng, X. Liang*, X. Zhang*, Artificial pancreas with engineered β-cell microspheres overexpressing PD-L1 and algae ameliorate type 1 diabetes, Cell Reports Physical Science, 2025, 102549（IF: 8. 9）.

2．Y. Ma#, F. Meng#, Z. Lin, Y. Chen, T. Lan, Z. Yang, R. Diao, X. Zhang, Q.Chen, C. Zhang, Y. Tian, C. Li, W. Fang, X. Liang*, X. Zhang*，Bioengineering Platelets Presenting PD-L1, Galectin-9 and BTLA to Ameliorate Type 1 Diabetes，Advanced Science, 2025, e2501139（IF: 14. 5）.

3. Y. Li#, Y# Tian, C. Li#, W. Fang, X. Li, Z. Jing, Z. Yang, X. Zhang, Y. Huang, J. Gong, F. Meng, L. Qi, X. Liang, L. Hou*, K. Lv*, X. Zhang*, In situ engineering of mRNA-CAR T cells using spleen-targeted ionizable lipid nanoparticles to eliminate cancer cells, Nano Today, 2024, 102518 (IF: 18. 9).

4. F. Meng, Z. Lin, Y. Ma, R. Che, C. Zhang, Y. Wei, X. Song, X. Liang*, and X. Zhang*. Engineered algae microrobots as photosynthetic living materials promote T cells' anti-tumor immunity. Cell Reports Physical Science, 2024, 102023 （IF: 8. 9）.

5. Z. Zhang, Z. Yang, L. Li, Z. Jing, Y. Ma, Y. Li, Z. Lin, W. Fang, X. Liang, B. Wu*, Y. Zheng*, X. Zhang*. Bioengineered Artificial Extracellular Vesicles Presenting PD-L1/Gal-9 Ameliorate New-onset Type 1 Diabetes. Diabetes，2024, db230987.（IF: 7. 7）.
6. W. Fang, Z. Jing, Y. Li, Z. Zhang, Z. Lin, Z. Yang, Y. Tian, C. Zhang, Y. Ma, L. Hou, F. Meng, X. Liang *, X. Zhang*，Harnessing Enucleated Cancer Cells as Trojan Horse Cell Vaccines，Cell Reports Physical Science,2024, 101752
7. Meng F, Li L, Zhang Z, Lin Z, Zhang J, Song X, Xue T, Xing C, Liang X*, Zhang X*. Biosynthetic neoantigen displayed on bacteria derived vesicles elicit systemic antitumour immunity, Journal of Extracellular Vesicles, 2022, 11(12): 12289.
BioMed iLab-Zhang Group at Sun Yat-sen University
Online Service
020-83271560
Telephone
020-83271560,020-83226059
Postcode
510080
Mail
zhangxd56@mail.sysu.edu.cn
联系QQ
258506508