BioMed iLab-Zhang Group at Sun Yat-sen University

47. Z. Jing#, W. Fang#, X. Li, #, Y. Tian, Y. Li, C. Zhang, Z. Yang, C. Li, Fanqiang Meng, X. Liang*, X. Zhang*, Artificial pancreas with engineered β-cell microspheres overexpressing PD-L1 and algae ameliorate type 1 diabetes, Cell Reports Physical Science, 2025, 102549（IF: 8. 9）.

46．Y. Ma#, F. Meng#, Z. Lin, Y. Chen, T. Lan, Z. Yang, R. Diao, X. Zhang, Q.Chen, C. Zhang, Y. Tian, C. Li, W. Fang, X. Liang*, X. Zhang*，Bioengineering Platelets Presenting PD-L1, Galectin-9 and BTLA to Ameliorate Type 1 Diabetes，Advanced Science, 2025, e2501139（IF: 14. 5）.

45. Y. Li#, Y# Tian, C. Li#, W. Fang, X. Li, Z. Jing, Z. Yang, X. Zhang, Y. Huang, J. Gong, F. Meng, L. Qi, X. Liang, L. Hou*, K. Lv*, X. Zhang*, In situ engineering of mRNA-CAR T cells using spleen-targeted ionizable lipid nanoparticles to eliminate cancer cells, Nano Today, 2024, 102518 (IF: 18. 9).

44. F. Meng, Z. Lin, Y. Ma, R. Che, C. Zhang, Y. Wei, X. Song, X. Liang*, and X. Zhang*. Engineered algae microrobots as photosynthetic living materials promote T cells' anti-tumor immunity. Cell Reports Physical Science, 2024, 102023 （IF: 8. 9）.
43. Z. Zhang, Z. Yang, L. Li, Z. Jing, Y. Ma, Y. Li, Z. Lin, W. Fang, X. Liang, B. Wu*, Y. Zheng*, X. Zhang*. Bioengineered Artificial Extracellular Vesicles Presenting PD-L1/Gal-9 Ameliorate New-onset Type 1 Diabetes. Diabetes，2024, db230987.（IF: 7. 7）.
42. Y., Wei, Z. Zhang, T. Xue, X. Chen, Y. Tian, Y. Li, Z. Jing, W. Fang, T. Fang, B. Li, Q. Chen, T. Lan, F. Meng*, X. Zhang*，X. Liang *. In situ synthesis of an immune-checkpoint blocker from engineered bacteria elicits a potent antitumor response. ACS Synthetic Biology，2024 （IF: 4. 7）.

41. W. Fang, Z. Jing, Y. Li, Z. Zhang, Z. Lin, Z.Yang, Y. Tian, C. Zhang, Y. Ma, L. Hou, F. Meng, X. Liang *, X. Zhang*，Harnessing Enucleated Cancer Cells as Trojan Horse Cell Vaccines,Cell Reports Physical Science,2024, 101752
40. Z. Lin, F. Meng, Y. Ma, C. Zhang, Z. Zhang, Z. Yang, Y. Li, L. Hou, Y. Xu, X. Liang, X. Zhang*，In situ immunomodulation of tumors with biosynthetic bacteria promote anti-tumor immunity，Bioactive Materials，2024, 32,12-239.
39.Fang T, Li B, Li M, Zhang Y, Jing Z, Li Y, Xue T, Zhang Z, Fang W, Lin Z, Meng F, Li L, Yang Y, Zhang X, Liang X*, Chen S*, Chen J*, Zhang X*. Engineered Cell Membrane Vesicles Expressing CD40 Alleviate System Lupus Nephritis by Intervening B Cell Activation, Small Methods, 2023: 2200925.
38. Fang W, Li L, Lin Z, Zhang Y, Jing Z, Li Y, Zhang Z, Hou L, Liang X*, Zhang X*, Zhang X*. Engineered IL-15/IL-15Rα-expressing cellular vesicles promote T cell anti-tumor immunity, Extracellular Vesicle, 2023, 2: 100021.
37. Meng F, Li L, Zhang Z, Lin Z, Zhang J, Song X, Xue T, Xing C, Liang X*, Zhang X*. Biosynthetic neoantigen displayed on bacteria derived vesicles elicit systemic antitumour immunity, Journal of Extracellular Vesicles, 2022, 11(12): 12289.
36. Z Jing#, Y Li#, Y Ma#, X Zhang, X Liang* and X Zhang*, Leverage biomaterials to modulate immunity for type 1 diabetes, Frontiers in Immunology, 2022.
35. B Li#, T Fang#, Y Li#, T Xue, Z Zhang, L Li, F Meng, J Wang, L Hou, X Liang*, X Zhang*, Z Gu*, Engineered T cell extracellular vesicles displaying PD-1 boost anti-tumor immunity, Nano Today, 2022
34. T. Xue, Z. Zhang, T. Fang, B. Li, Y. Li, L. Li, Y. Jiang, F. Duan, F. Meng*, X. Liang*, X. Zhang*, Cellular vesicles expressing PD-1-blocking scFv reinvigorate T cell immunity against cancer, Nano Research, 2022.
33. L. Li , Q. Miao , F. Meng , B. Li, T. Xue, T. Fang, Z. Zhang, J. Zhang, X. Ye, Y. Kang, X. Zhang, Q. Chen, X. Liang*, H. Chen*, X. Zhang*. Genetic engineering cellular vesicles expressing CD64 as checkpoint antibody carrier for cancer immunotherapy. Theranostics, 2021, 11(12):6033-6043.
32. X. Zhang#, Yang Kang#, Jinqiang Wang, Junjie Yan, Qian Chen, Hao Cheng*, Peng Huang*, and Zhen Gu*，Engineering PD-L1-expressing Platelets Reverse New-Onset Type 1 Diabetes, Advanced Materials, 2020, 1907692.
31. X. Ye, X. Liang, Q. Chen, Q. Miao, X. Chen, X. Zhang*, L. Mei*, Surgical Tumor-Derived Personalized Photothermal Vaccine Formulation for Cancer Immunotherapy, ACS Nano, 13 2019, 2956-2968.
30. X. Liang, X. Ye, C. Wang, C. Xing, Q. Miao, Z. Xie, X. Chen, X. Zhang*, H. Zhang*, L. Mei*, Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation, Journal of Controlled Release, 2019, 296 150-161.
29. Q. Chen, C. Wang, X. Zhang, G. Chen, Q. Hu, H. Li, J. Wang, D. Wen, Y. Zhang, Y. Lu, G. Yang, C. Jiang, G. Dotti, Z. Gu, In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment, Nature Nanotechnology, 14 (2019) 89-97.
28. X. Zhang, C. Wang, J. Wang, Q. Hu, B. Langworthy, Y. Ye, W. Sun, J. Lin, P. Huang*, Z. Gu*, PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy. Advanced Materials, 2018, 1707112.
27. X. Zhang#, J. Wang#, Z. Chen, Q. Hu, C. Wang, J. Yan, P. Huang* & Z. Gu*, Engineering PD-1-Presenting Platelets for Cancer Immunotherapy, Nano Letters, 2018, 18,5716-5725.
26. J. Yan#, X. Zhang#, Y. Liu, Y. Ye, J. Yu, Q. Chen, J. Wang, Y. Zhang, Q. Hu, Y. Kang, M.Yang* and Z. Gu*, Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy. Nano Research, 2018.
25. L. Jiang, X. Liang, G. Liu, J. Zhang, X. Ye, X. Chen, Q. Miao, X. Zhang*, Lin Mei*, The mechanism of lauric acid-modified protein nanocapsules escape from intercellular trafficking vesicles and its implication for drug delivery. Drug Delivery, 2018.
24. S. Yu, C. Wang, J. Yu, J. Wang, Y. Lu, Y. Zhang, X. Zhang, Q. Hu, W. Sun, C. He, X.  Chen, Z. Gu, Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade, Advanced Materials, (2018) e1801527.
23. W. Chen, Y. Wang, M. Qin, X. Zhang, Z. Zhang, X. Sun, Z. Gu, Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy, ACS Nano, (2018).
22. Z. Chen, J. Wang, W. Sun, E. Archibong, A.R. Kahkoska, X. Zhang, Y. Lu, F.S. Ligler, J.B. Buse, Z. Gu, Synthetic beta cells for fusion-mediated dynamic insulin secretion, Nature Chemical Biology, 14 (2018) 86-93
21. J. Wang, Y. Ye, J. Yu, A.R. Kahkoska, X. Zhang, C. Wang, W. Sun, R.D. Corder, Z. Chen, S.A. Khan, J.B. Buse, Z. Gu, Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery, ACS Nano, (2018).
20. C. Wang, J. Wang, X. Zhang, S. Yu, D. Wen, Q. Hu, Y. Ye, H. Bomba, X. Hu, Z. Liu, G. Dotti, Z. Gu, In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy, Science Translational Medicine, 10 (2018).
19. X. Zhang#, X. Liang#, J. Gu#, D. Chang, J. Zhang, Z. Chen, Y. Ye, C. Wang, W. Tao, X. Zeng, G. Liu, Y. Zhang, L. Mei*, Z. Gu*, Investigation and intervention of autophagy to guide cancer treatment with nanogels, Nanoscale, 9 (2017) 150-163.
18. J. Zhang, D. Chang, Y. Yang, X. Zhang*, W. Tao, L. Jiang, X. Liang, H. Tsai, L. Huang*, L. Mei*, Systematic investigation on the intracellular trafficking network of polymeric nanoparticles, Nanoscale, 9 (2017) 3269-3282.
17. L. Zhang, W. Hao, L. Xu, Y. Gao, X. Wang, D. Zhu, Z. Chen, X. Zhang*, H. Chen*, L. Mei*, A pH-sensitive methenamine mandelate-loaded nanoparticle induces DNA damage and apoptosis of cancer cells, Acta Biomaterialia,17 (2017) 30518-4.
16. Y. Ye, C. Wang, X. Zhang, Q. Hu, Y. Zhang, Q. Liu, D. Wen, J. Milligan, A. Bellotti, L. Huang, G. Dotti, Z. Gu, A melanin-mediated cancer immunotherapy patch, Science Immunology, 2 (2017).
15. W. Cheng, C. Liang, L. Xu, G. Liu, N. Gao, W. Tao, L. Luo, Y. Zuo, X. Wang, X. Zhang, X. Zeng, L. Mei, TPGS-Functionalized Polydopamine-Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance, Small, 13 (2017).
14. W. Tao, X. Zhu, X. Yu, X. Zeng, Q. Xiao, X. Zhang, X. Ji, X. Wang, J. Shi, H. Zhang, L. Mei, Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics, Advanced Materials, 29 (2017).
13. J. Zhang#, X. Zhang#, *, G. Liu, D. Chang, X. Liang, X. Zhu, W. Tao, L. Mei*, Intracellular Trafficking Network of Protein Nanocapsules: Endocytosis, Exocytosis and Autophagy, Theranostics, 6 (2016) 2099-2113.
12. X. Zhang#, H. Zhang#, X. Liang, J. Zhang, W. Tao, X. Zhu, D. Chang, X. Zeng, G. Liu, L. Mei, Iron Oxide Nanoparticles Induce Autophagosome Accumulation through Multiple Mechanisms: Lysosome Impairment, Mitochondrial Damage, and ER Stress, Molecular Pharmaceutics, 13 (2016) 2578-2587.
11. W. Tao, X. Zeng, J. Wu, X. Zhu, X. Yu, X. Zhang, J. Zhang, G. Liu, L. Mei, Polydopamine-Based Surface Modification of Novel Nanoparticle-Aptamer Bioconjugates for In Vivo Breast Cancer Targeting and Enhanced Therapeutic Effects, Theranostics, 6 (2016) 470-484.
10. X. Zhu, X. Zeng, X. Zhang, W. Cao, Y. Wang, H. Chen, T. Wang, H.I. Tsai, R. Zhang, D. Chang, S. He, L. Mei, X. Shi, The effects of quercetin-loaded PLGA-TPGS nanoparticles on ultraviolet B-induced skin damages in vivo, Nanomedicine : nanotechnology, biology, and medicine, 12 (2016) 623-632.
9. X. Liang, Y. Yang, L. Wang, X. Zhu, X. Zeng, H. Chen, X. Zhang* & L. Mei*. PH-triggered burst intracellular release from hollow microspheres to induce autophagic cancer cell death. Journal of Materials Chemistry B，3（2015）9383-9396.
8. J. Zhang, W. Tao, Y. Chen, D. Chang, T. Wang, X. Zhang, L. Mei, X. Zeng, L. Huang, Doxorubicin-loaded star-shaped copolymer PLGA-vitamin E TPGS nanoparticles for lung cancer therapy, Journal of Materials Science. Materials in medicine, 26 (2015) 165.
7. X. Zhang#, Y. Dong#, X. Zeng, X. Liang, X. Li, W. Tao, H. Chen, Y. Jiang, L. Mei, S.S. Feng, The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment, Biomaterials, 35 (2014) 1932-1943.
6. X. Zhang#, X. Zeng, X#. Liang, Y. Yang, X. Li, H. Chen, L. Huang, L. Mei, S.S. Feng, The chemotherapeutic potential of PEG-b-PLGA copolymer micelles that combine chloroquine as autophagy inhibitor and docetaxel as an anti-cancer drug, Biomaterials, 35 (2014) 9144-9154.
5. X. Zhang#, Y. Yang#, X. Liang, X. Zeng, Z. Liu, W. Tao, X. Xiao, H. Chen, L. Huang, L. Mei, Enhancing therapeutic effects of docetaxel-loaded dendritic copolymer nanoparticles by co-treatment with autophagy inhibitor on breast cancer, Theranostics, 4 (2014) 1085-1095.
4. L. Mei, X. Zhang, S.S. Feng, Autophagy inhibition strategy for advanced nanomedicine, Nanomedicine (Lond), 9 (2014) 377-380.
3. Z. Wang, Y. Wu, H. Wang, Y. Zhang, L. Mei, X. Fang, X. Zhang, F. Zhang, H. Chen, Y. Liu, Y. Jiang, S. Sun, Y. Zheng, N. Li, L. Huang, Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility, PNAS, 111 (2014) E89-98.
2. H. Zhu, H. Chen, X. Zeng, Z. Wang, X. Zhang, Y. Wu, Y. Gao, J. Zhang, K. Liu, R. Liu, L. Cai, L. Mei, S.S. Feng, Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance, Biomaterials, 35 (2014) 2391-2400.
1. B. Qiu, M. Ji, X. Song, Y. Zhu, Z. Wang, X. Zhang, S. Wu, H. Chen, L. Mei, Y. Zheng, Co-delivery of docetaxel and endostatin by a biodegradable nanoparticle for the synergistic treatment of cervical cancer, Nanoscale Research Letters, 7 (2012) 666.
BioMed iLab-Zhang Group at Sun Yat-sen University
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